Does installing Ghost on CloudPanel make sense?
I'm wondering if it's a good idea in terms of performance, configuration ease, and overall management. Has anyone tried it and can share their experience?

Yes, installing Ghost on CloudPanel works well and runs quite stable.
In fact, CloudPanel has an official guide specifically for setting up Ghost. Since it uses Nginx instead of Apache and supports Node.js out of the box, it integrates smoothly with Ghost.

You can check out the documentation here:
Ghost | CloudPanel | Documentation
Let me know if you need help with the setup!